Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model
Identifieur interne : 000995 ( Main/Exploration ); précédent : 000994; suivant : 000996Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model
Auteurs : H. S. Li ; Denise I. T. Kuok ; M. C. Cheung ; Mandy M. T. Ng ; K. C. Ng ; Kenrie P. Y. Hui ; J. S. Malik Peiris ; Michael C. W. Chan ; John M. NichollsSource :
- Antiviral Research [ 0166-3542 ] ; 2018.
Descripteurs français
- KwdFr :
- Antiviraux (pharmacologie), Appareil respiratoire (virologie), Bronches (physiologie), Bronches (virologie), Ciclosporine (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Humains, Interféron alpha (pharmacologie), Poumon (physiologie), Poumon (virologie), Réplication de l'ADN, Réplication virale (), Techniques de culture cellulaire.
- MESH :
- pharmacologie : Antiviraux, Ciclosporine, Interféron alpha.
- physiologie : Bronches, Poumon.
- virologie : Appareil respiratoire, Bronches, Poumon.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Réplication de l'ADN, Réplication virale, Techniques de culture cellulaire.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Bronchi (physiology), Bronchi (virology), Cell Culture Techniques, Cyclosporine (pharmacology), DNA Replication, Humans, Interferon-alpha (pharmacology), Lung (physiology), Lung (virology), Middle East Respiratory Syndrome Coronavirus (drug effects), Respiratory System (virology), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Cyclosporine, Interferon-alpha.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- physiology : Bronchi, Lung.
- virology : Bronchi, Lung, Respiratory System.
- Cell Culture Techniques, DNA Replication, Humans.
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has emerged as a coronavirus infection of humans in the past 5 years. Though confined to certain geographical regions of the world, infection has been associated with a case fatality rate of 35%, and this mortality may be higher in ventilated patients. As there are few readily available animal models that accurately mimic human disease, it has been a challenge to ethically determine what optimum treatment strategies can be used for this disease. We used in-vitro and human ex-vivo explant cultures to investigate the effect of two immunomodulatory agents, interferon alpha and cyclosporine, singly and in combination, on MERS-CoV replication. In both culture systems the combined treatment was more effective than either agent used alone in reducing MERS-CoV replication. PCR SuperArray analysis showed that the reduction of virus replication was associated with a greater induction of interferon stimulated genes. As these therapeutic agents are already licensed for clinical use, it may be relevant to investigate their use for therapy of human MERS-CoV infection.
Url:
DOI: 10.1016/j.antiviral.2018.05.007
PubMed: 29772254
PubMed Central: 7113667
Affiliations:
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Le document en format XML
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S." last="Li">H. S. Li</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Kuok, Denise I T" sort="Kuok, Denise I T" uniqKey="Kuok D" first="Denise I. T." last="Kuok">Denise I. T. Kuok</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Cheung, M C" sort="Cheung, M C" uniqKey="Cheung M" first="M. C." last="Cheung">M. C. Cheung</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Ng, Mandy M T" sort="Ng, Mandy M T" uniqKey="Ng M" first="Mandy M. T." last="Ng">Mandy M. T. Ng</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Ng, K C" sort="Ng, K C" uniqKey="Ng K" first="K. C." last="Ng">K. C. Ng</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Hui, Kenrie P Y" sort="Hui, Kenrie P Y" uniqKey="Hui K" first="Kenrie P. Y." last="Hui">Kenrie P. Y. Hui</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C. W." last="Chan">Michael C. W. Chan</name><affiliation><nlm:aff id="aff1">School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. Nicholls</name><affiliation><nlm:aff id="aff2">Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region</nlm:aff><wicri:noCountry code="subfield">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Bronchi (physiology)</term><term>Bronchi (virology)</term><term>Cell Culture Techniques</term><term>Cyclosporine (pharmacology)</term><term>DNA Replication</term><term>Humans</term><term>Interferon-alpha (pharmacology)</term><term>Lung (physiology)</term><term>Lung (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Respiratory System (virology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term><term>Appareil respiratoire (virologie)</term><term>Bronches (physiologie)</term><term>Bronches (virologie)</term><term>Ciclosporine (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Humains</term><term>Interféron alpha (pharmacologie)</term><term>Poumon (physiologie)</term><term>Poumon (virologie)</term><term>Réplication de l'ADN</term><term>Réplication virale ()</term><term>Techniques de culture cellulaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Cyclosporine</term><term>Interferon-alpha</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Ciclosporine</term><term>Interféron alpha</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bronches</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bronchi</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Bronches</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchi</term><term>Lung</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Culture Techniques</term><term>DNA Replication</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Réplication de l'ADN</term><term>Réplication virale</term><term>Techniques de culture cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has emerged as a coronavirus infection of humans in the past 5 years. Though confined to certain geographical regions of the world, infection has been associated with a case fatality rate of 35%, and this mortality may be higher in ventilated patients. As there are few readily available animal models that accurately mimic human disease, it has been a challenge to ethically determine what optimum treatment strategies can be used for this disease. We used in-vitro and human ex-vivo explant cultures to investigate the effect of two immunomodulatory agents, interferon alpha and cyclosporine, singly and in combination, on MERS-CoV replication. In both culture systems the combined treatment was more effective than either agent used alone in reducing MERS-CoV replication. PCR SuperArray analysis showed that the reduction of virus replication was associated with a greater induction of interferon stimulated genes. As these therapeutic agents are already licensed for clinical use, it may be relevant to investigate their use for therapy of human MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. Al-Tawfiq</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. Al-Tawfiq</name></author><author><name sortKey="Momattin, H" uniqKey="Momattin H">H. Momattin</name></author><author><name sortKey="Dib, J" uniqKey="Dib J">J. Dib</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y M" uniqKey="Arabi Y">Y.M. Arabi</name></author><author><name sortKey="Balkhy, H H" uniqKey="Balkhy H">H.H. 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Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C. W." last="Chan">Michael C. W. Chan</name><name sortKey="Cheung, M C" sort="Cheung, M C" uniqKey="Cheung M" first="M. C." last="Cheung">M. C. Cheung</name><name sortKey="Hui, Kenrie P Y" sort="Hui, Kenrie P Y" uniqKey="Hui K" first="Kenrie P. Y." last="Hui">Kenrie P. Y. Hui</name><name sortKey="Kuok, Denise I T" sort="Kuok, Denise I T" uniqKey="Kuok D" first="Denise I. T." last="Kuok">Denise I. T. Kuok</name><name sortKey="Li, H S" sort="Li, H S" uniqKey="Li H" first="H. S." last="Li">H. S. Li</name><name sortKey="Ng, K C" sort="Ng, K C" uniqKey="Ng K" first="K. C." last="Ng">K. C. Ng</name><name sortKey="Ng, Mandy M T" sort="Ng, Mandy M T" uniqKey="Ng M" first="Mandy M. T." last="Ng">Mandy M. T. Ng</name><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. Nicholls</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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